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阜外医院

  • 姓 名:

    陈敬洲

  • 单 位:

    中国医学科学院阜外医院

  • 教职岗位:

    长聘副教授

  • 聘任时间:

    2023-01-01

  • 一级学科:

    生物学

  • 二级学科:

    生物化学与分子生物学

  • 联系方式:

    chendragon1976@aliyun.com

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2009031289

个人简介

陈敬洲,研究员,博士研究生导师,协和学者特聘教授,准长聘系列长聘副教授,国家万人计划科技创新领军人才。现任国家心血管病中心华中分中心副主任,国家心血管病中心科研产业处副处长,心血管疾病全国重点实验室副主任,再生医学重点实验室副主任,阜外医院教育处处长。
     曾获茅以升北京青年科技奖。获得973课题,国家自然科学基金委重点项目,国家科技重大专项(四大慢病重大专项)课题等项目资助。


主要研究内容

长期从事心脑血管疾病遗传、环境危险因素及其发病机制研究,尤其在高血压脑出血血管病变防控这一中国特色重大需求而又缺乏关注的领域,并取得了系列成绩。主要研究内容为高血压靶器官损害,高血压脑出血管病变机制及干预。研究成果在Circulation, iMeta, Nat Commun, Theranostics, Autophagy, Hypertension等权威期刊发表。获省部级科技奖5项,国家发明专利10项。培养博士、硕士、博士后26余名。任中国分子心脏病学杂志(编辑委员会)副主编 。


代表性成果

中国足球彩票

图片

1. Meng Zhang#, Jingyuan Ning#, Jing Liu, Yingying Sun, Ning Xiao, Haochen Xu*, Jingzhou Chen*. Peripheral blood immune landscape and NXPE3 as a novel biomarker for hypertensive intracerebral hemorrhage risk prediction and targeted therapy. iMeta. 2025 Apr 11;4(3):e70030. (IF:33.2)

2. Dongsheng Ni#, Zhaolai Qi#, Shuang Ma#, Yuefeng Wang, Dehuan Liang, Xiyue Zhang, Yong Man, Jingzhou Chen*, Kefei Dou*, Guoping Li*. Membrane-associated ringeCHetype finger 2 protects against metabolic dysfunctionassociated fatty liver disease by targeting fatty acid synthase. Molecular Metabolism. 2025 Jun:96:102137. (IF:6.6)

3. Bai CX#, Su M#, Zhang YH#, Lin YH#,Sun YY,Song L,Xiao N, Xu HC,Wen HY,Zhang M,Ping JD, Liu J,Hui RT,Li H*, Chen JZ*.Oviductal Glycoprotein 1 Promotes Hypertension by Inducing ascular Remodeling Through an Interaction With MYH9.Circulation.2022 Nov ;146(18):1367-1382. (IF:39.918)

4. Chen Z#, Ouyang C#, Zhang H, Gu Y, Deng Y, Du C, Cui C, Li S, Wang W, Kong W, Chen JZ*, Cai J*, Geng B*. Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy. Autophagy. 2022 Jan 28:1-18. (IF:13.391)

5. Li H#, Xu HC#, Wen HY#, Wang H, Zhao R, Sun YY, Bai CX, Ping JD, Song L, Luo MY*, Chen JZ*. Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm. Theranostics. 2021 Sep 21;11(19):9587-9604. (IF:11.6)

6. Song L#, Li H#, Suo MM, Sun YY, Su M, Song Y, Xiao N, Hui RT, Qin CC*, Chen JZ*. A functional variant of the long noncoding RNA AL110200 is associated with the risk of ischaemic stroke recurrence. Eur J Neurol. 2021 Aug; 28(8): 2708-2715.(IF:6.288)

7. Xiao N#, Liu TL, Li H, Xu HC, Ge J, Wen HY, Bai CX, Song L, Sun YY, Zhang YH, Hui RT, Song WH*, Chen JZ*. Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. Transl Stroke Res. 2020 Oct;11(5):1077-1094. (IF:6.829)

8. Li H#, Xu H#, Li Y#, Jiang Y#, Hu Y, Liu T, Tian X, Zhao X, Zhu Y, Wang S, Zhang C, Ge J, Wang X, Wen H, Bai C, Sun Y, Song L, Zhang Y, Hui R, Cai J, Chen JZ*. Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysms. Nat Commun. 2020 Jun 25;11(1):3218. (IF:14.919)

9. Liu T#, Wen H#, Li H#, Xu H, Xiao N, Liu R, Chen L, Sun Y, Song L, Bai C, Ge J, Zhang Y, Chen JZ*. Oleic Acid Attenuates Ang II (Angiotensin II)-Induced Cardiac Remodeling by Inhibiting FGF23 (Fibroblast Growth Factor 23) Expression in Mice. Hypertension. 2020 Mar;75(3):680-692. (IF:10.19)

10. Li H#, Xu HC#, Wen HY#, Liu TL, Sun YY, Xiao N, Bai CX, Ge J, Wang XL, Song L, Song Y, Zhang YH, Chen JZ*. Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2019 Mar;39(3):547-561. (IF:6.04)