吴志宏，中国医学科学院北京协和医院主任医师，外科学生物医学工程专业博士生导师，临床研究所干细胞平台主任、疑难重症及罕见病全国重点实验室PI。曾获国家科技进步二等奖、中国21世纪重要医学成就、教育部一等奖、北京市科技进步二等奖、华夏科技进步二等奖等多项省部级以上奖励。主持国家自然科学基金重点项目、重点研发、北自然重点等40余项项目。

长期从事运动系统相关疾病的遗传学病因及其精准诊疗，组织建立的“系统解析脊柱侧凸及相关合并症（DISCO）”国际多中心协作组为全面揭示脊柱畸形及相关疾病的遗传学病因及机制、实现脊柱畸形的精准诊疗打下坚实基础。发现TBX6基因变异是目前为止导致先天性脊柱侧凸的最重要致病因素；鉴定骨骼畸形诊疗新靶点，研发生物技术为基础的创新型治疗方法。共发表文章300余篇，总IF>700。参加编写著作14部（副主编3部），获得授权专利41项。

中国足球彩票

1.Liu J#, Liu F#, Li C#, Li Z, Li T, Wu Y, Wu D, Huang Y, Chen H, Wang H*, Lai Y*, Wu Z*. 3D-printed magnetic scaffolds promote bone and vessel regeneration through CRYAB/PI3K-AKT and NF-κB pathways identified by proteomics. Bioact Mater. 2025; 56:277-293. (IF=20.5)

2.Zhao S#, Zhao H#, Zhao L#, Cheng X#, Zheng Z, Wu M, Wen W, Wang S, Zhou Z, Xie H, Ruan D, Li Q, Liu X, Ou C, Li G, Zhao Z, Chen G, Niu Y, Yin X, Hu Y, Zhang X; Deciphering disorders Involving Scoliosis and COmorbidities (DISCO) study; Liu P, Qiu G, Liu W, Zhao C, Wu Z*, Zhang J*, Wu N*. Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine. Nat Commun. 2024; 15(1):1125. (IF=15.7)

3.Wu XD#, Kang L, Tian J, Wu Y, Huang Y, Liu J, Wang H*, Qiu G*, Wu Z*. Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway. Mater Today Bio. 2022; 15:100319. (IF=8.2)

4.Gao Y#, Zhao H#, An K#, Liu Z#, Hai L#, Li R, Zhou Y, Zhao W, Jia Y, Wu N, Li L, Ying J, Wang J, Xu B, Wu Z*, Tong Z*, He J*, Sun Y*. Whole-genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer. Clin Transl Med. 2022; 12(8): e1014. (IF=10.6)

5.Sun L#, Huang Y#, Zhao S, Zhao J, Yan Z, Guo Y, Lin M, Zhong W, Yin Y, Chen Z, Zhang N, Zhang Y, Zhao Z, Li Q, Wang L, Dong X, Li Y, Li X, Qiu G; DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) study group, Zhang TJ, Wu Z*, Tian W*, Wu N*. Deciphering the mutational signature of congenital limb malformations. Mol Ther Nucleic Acids. 2021; 24:961-970. (IF=10.183)

6.Wu D#, Chang X#, Tian J, Kang L, Wu Y, Liu J, Wu X, Huang Y, Gao B, Wang H*, Qiu G*, Wu Z*. Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis. J Nanobiotechnology. 2021; 19(1):209. (IF=9.429, C100)

7.Leng L#, Cao R#, Ma J#, Mou D#, Zhu Y, Li W, Lv L, Gao D, Zhang S, Gong F, Zhao L, Qiu B, Xiang H, Hu Z, Feng Y, Dai Y, Zhao J, Wu Z*, Li H*, Zhong W*. Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther. 2020; 5(1):240. (IF=18.187)

8.Huang Z#, He Y#, Chang X#, Liu J, Yu L, Wu Y, Li Y, Tian J, Kang L, Wu D, Wang H*, Wu Z*, Qiu G. A Magnetic Iron Oxide/Polydopamine Coating Can Improve Osteogenesis of 3D-Printed Porous Titanium Scaffolds with a Static Magnetic Field by Upregulating the TGFβ-Smads Pathway. Adv Healthc Mater. 2020; 9(14). (IF=9.933)

9.Wu D#, Kang L, Tian J, Wu Y, Liu J, Li Z, Wu X, Huang Y, Gao B, Wang H*, Wu Z*, Qiu G. Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe3O4 Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p. Int J Nanomedicine. 2020; 15:7979-7993. (IF=6.4, C100)

10.Wu N#, Ming X#, Xiao J#, Wu Z#, Chen X#, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev Z S, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy K W, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton V R, Wang H, Ming Y, Kulkarni S, Zhong T P, Giampietro P F, Dunwoodie S L, Cheung S W, Zhang X, Jin L, Lupski J R, Qiu G*, Zhang F*. TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med. 2015; 372(4):341-50. (IF=59.558, C100, F1000)