高小攀，研究员，现任中国医学科学院&北京协和医学院助理教授、中国医学科学院病原生物学研究所课题组长。博士/硕士研究生导师。主持承担国家科技重大专项课题1项，国家自然科学基金3项、北京市自然基金2项、以第一作者和通讯作者在Nature (2024) ,Molecular Cell (2025), Nature Communications (2021, 2022, 2024), Cell Discovery (2024), Cell Reports (2022, 2024), Protein & Cell (2022)等期刊上发表SCI近30篇。授权发明专利5项。兼任中国畜牧兽医学会兽医公共卫生分会第四届理事会理事，中华医学会结核病学分会第十八届委员会科技创新转化专业委员会委员。

长期从事主要从事细胞保守的抗病毒免疫机制及其应用。围绕病原入侵和宿主抗病毒免疫的共性机制及其潜在应用，开展了系列研究工作。研究结果为新型基因编辑，基因检测以及基于药物研发提供思路。

中国足球彩票

1.Gao X#，*, Zhu K#, Zhang W#, Wang L#, Wang L, Hua L, Niu T, Qin B, Yu X*, Zhu H*, Cui S*. RNA anti-CRISPRs deplete Cas proteins to inhibit the CRISPR-Cas system. Mol Cell. 2025 Dec 30: S1097-2765(25)00979-7. (SCIE)

2.Gao X#, Shang K#, Zhu K#, Wang L#, Mu Z#, Fu X, Yu X, Qin B, Zhu H*, Ding W*, Cui S*. Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature. 2024 Jan;625(7996):822-831. (SCIE)

3.Gao X#，*, Zhu K#, Wang L#, Shang K, Hua L, Qin B, Zhu H*, Ding W*, Cui S*. Structural basis for the interaction between human coronavirus HKU1 spike receptor binding domain and its receptor TMPRSS2. Cell Discov. 2024 Aug 8;10(1):84. (SCIE)

4.Gao X#, Wang B#, Zhu K#, Wang L#, Qin B, Shang K, Ding W*, Wang J*, Cui S*. The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction. Nat Commun. 2024 May 16;15(1):4176. (SCIE)

5.Zhu K#, Song L#, Wang L#, Hua L#, Luo Z, Wang T, Qin B, Yuan S, Gao X*, Mi W*, Cui S*. SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. Acta Pharm Sin B. 2024 Sep;14(9):4164-4173. (SCIE)

6.Gao X#, Tian H#, Zhu K#, Li Q, Hao W, Wang L, Qin B, Deng H*, Cui S*. Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport. Nat Commun. 2022 Aug 15;13(1):4782. (SCIE)

7.Zhang C#, Yang F#, Wojdyla JA, Qin B, Zhang W, Zheng M, Cao W, Wang M, Gao X*, Zheng H*, Cui S*. An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein. Cell Rep. 2022 Jul 5;40(1):111030. (SCIE)

8.Yuan S#, *, Gao X#, Tang K#, Cai JP#, Hu M, Luo P, Wen L, Ye ZW, Luo C, Tsang JO, Chan CC, Huang Y, Cao J, Liang R, Qin Z, Qin B, Yin F, Chu H, Jin DY, Sun R, Chan JF*, Cui S*, Yuen KY*. Targeting papain-like protease for broad-spectrum coronavirus inhibition. Protein Cell. 2022 Dec;13(12):940-953. (SCIE)

9.Gao X#, Qin B#, Chen P#, Zhu K, Hou P, Wojdyla JA, Wang M, Cui S*. Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021 Jan;11(1):237-245. (C100), (SCIE)

10.Gao X#, Zhu K#, Qin B#, Olieric V, Wang M, Cui S*. Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. Nat Commun. 2021 May 14;12(1):2843. (SCIE)