雷晓波，研究员，博士研究生导师。2006年在中国科学院动物研究所获得博士学位，主要从事细胞凋亡的分子机制研究。2006年进入中国医学科学院病原生物学研究所工作升为助理研究员，2012年聘为副研究员，2018年聘为研究员。目前担任中国微生物学会病毒学专业委员会委员和中华预防医学会医学病毒学分会青年小组委员。两次入选全球前2%顶尖科学家榜单。

主要从事冠状病毒和肠道病毒的基础研究，聚焦重大和新发突发传染病病毒的入侵、复制及与宿主相互作用的研究。系统揭示重要呼吸道病毒感染中宿主天然免疫应答与病毒免疫逃逸的博弈规律，发现多个影响病毒入侵、复制的关键宿主因子。承担国家科技重大专项和国自然等多项课题，在Nat Commun、STTT和Cell Rep等SCI收录杂志上发表SCI论文30余篇，9篇他引大于100，总被引用7100余次，H指数30（Research Gate）。研究成果入选 2020年Springer Nature中国学者年度高影响力研究。

中国足球彩票

1.Chen YJ#, Shi YJ#, Zuo XY, Dong XJ, Xiao X, Chen L, Xiang ZC, Ren LL, Zhou Z, Wei WS*, Lei XB*, and Wang JW*. UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation. J Virol. 2025 Jul 22; 99(7): e0074125.

2.Ma RY#, Zhang XY#, Li RN, Dong XJ, Wang WJ, Jiang Q, Xiao X, Shi YJ, Chen L, Zheng T, Xiang ZC, Lei XB*, and Wang JW*. PLSCR1 suppresses SARS-CoV-2 infection by downregulating cell surface ACE2. J Virol. 2025 Mar 18; 99(3): e0208524.

3.Wang XH#, Hu ZL#, Zhang W#, Wu SW, Hao YJ, Xiao Xia, Li JJ, Yu XL, Yang CK, Wang JF, Zhang HY, Ma F, Shi WF, Wang JW, Lei XB*, Zhang XH*, and He SD*. Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16. J Cell Biol. 2023 Dec 4; 222(12): e202303108.

4.Zhang D#, Qiao LL#, Lei XB#, Dong XJ, Tong YG, Wang JW*, Wang ZY*, and Zhou RH*. Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein. Nat Commun. 2023 Jun 22; 14(1):3715.

5.Wu ZC#, Lei XB#, Wang X#, Zhang ZY, Li YM, Gao LF, Liang XH, Wang PH, Wang JW*, and Ma CH*. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19.

6.Guo SS#, Lei XB#, Chan Y#, Zhao JY#, Wang J#, Dong XJ, Liu Q, Zhang ZX, Wang LD, Yi DR, Ma L, Li QJ, Zhang YX, Ding JW, Liang C, Li XY, Guo F*, Wang JW*, and Cen S*. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis. Signal Transduct Target Ther. 2022 Dec 27;7(1):400.

7.Zhou Z#, Zhang XY#, Lei XB#, Xiao X#, Jiao T, Ma RY, Dong XJ, Jiang Q, Wang WJ, Shi YJ, Zheng T, Rao J, Xiang ZC, Ren LL, Deng T, Jiang ZF, Dou ZX, and Wei WX*, and Wang JW*. Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. Signal Transduct Target Ther. 2021 Nov 3; 6(1):382.

8.Wang WJ#, Zhou Z#, Xiao X#, Tian ZQ, Dong XJ, Wang CH, Li L, Ren LL, Lei XB*, Xiang ZC*, and Wang JW*. SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation. Cell Mol Immunol. 2021 Apr; 18(4):945-953. (C100)

9.Lei XB#, Dong XJ#, Ma RY#, Wang WJ, Xiao X, Tian ZQ, Wang CH, Wang Y, Li L, Ren LL, Guo F, Zhao ZD, Zhou Z*, Xiang ZC*, and Wang JW*. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun. 2020 Jul 30; 11(1): 3810. (ESI, C100)

10.Ou XY#, Liu Y#, Lei XB#, Li P, Mi D, Ren LL, Guo L, Guo RX, Chen T, Hu JX, Xiang ZC, Mu ZX, Chen X, Chen JY, Hu KP, Jin Q*, Wang JW*, and Qian ZH*. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27; 11(1):1620. (ESI, C100)