吕家迪，准聘助理教授，副研究员，博士研究生导师。曾获北京市科学技术奖自然科学奖一等奖、中国免疫学会青年学者奖，入选中国科协青年人才托举工程。获得国家自然科学基金优秀青年基金项目、国家自然科学基金原创探索计划项目、国家自然科学基金面上项目等项目资助。

长期从事生物机械力学与肿瘤免疫的研究；利用生物机械力学原理，针对肿瘤细胞休眠、干性的物理特征以及免疫逃逸等方面，做出了系列创新性、可持续性的研究工作，发现物理的软度是肿瘤干细胞独特的标志，先后阐明了免疫因子和细胞外基质硬度参与调控肿瘤干细胞休眠的机制，并揭示生物机械力驱动的表观遗传修饰调控原始肿瘤细胞形成差异免疫原性的过程。

中国足球彩票

1.Lv J#, Si T#, Wang D#, Zhang C, Zhou Y, Yu J, Jiang Y, Wu D, Zhou L, Wang Z, Zhou N, Chen J, Wei K, Zhang H, Ma J, Tang K, Cao X,Huang B*. Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells. Immunity. 2025 Aug 5:S1074-7613(25)00327-9 (IF=26.3)

2.Lv, J#, Zhou, Y.#, Zhou, N., Wang, Z., Chen, J., Zhang, Y., Zhang, H. & Huang, B*. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci. Transl. Med. 15, eabq6024 (IF=17.1)

3.Lv J#, Liu Y.#, Mo S.#, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B*. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72. (IF=11.0)

4.Lv, J#, Liu, Y.#, Cheng, F.#, Li, J., Zhou, Y., Zhang, H., Xie, J., Fang, Y., Zhang, H., Wang, N., Liu, Y. & Huang, B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J. 40, e106123 (IF=28.2)

5.Lv, J#, Liu, X.#, Zhou, Y.#, Cheng, F., Chen, H., Zhou, N., Chen, J. & Huang, B*. YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation. Research 6, 0215  (IF=22.0)

6.Lv, J#, Wang, Z.#, Qu, Y.#, Zhu, H., Zhu, Q., Tong, W., Liu, J., Liu, Y., Qin, C*. & Huang, B*. Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages. Cell Discov. 7, 24 (IF=38.1)

7.Lv, J#, Yu, P.#, Wang, Z., Deng, W., Bao, L., Tong, W. M., Liu, Y., Qin, C. * & Huang, B*. ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques. Cell Mol. Immunol. 18, 1308-1310 (IF=22.0)

8.Wang, Z.#, Lv, J.#, Yu, P., Qu, Y., Zhou, Y., Liu, J., Tong, W. M., Qin, C. * & Huang, B*. SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol. Immunol. 19, 210-221 (IF=14.0)

9.Liu, Y.#, Lv, J.#, Liu, J., Li, M., Xie, J., Qin, C., Tong, W. M. & Huang, B*. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19. Cell Res. 30, 1078-1087 (IF=25.6).

10.Liu, Y.#, Lv, J.#, Liu, J.#, Liang, X., Jin, X., Zhang, H., Hu, Z. W., Cao, X., Qin, F. X. & Huang, B. * STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J. Clin. Invest. 128, 1057-1073 (IF=13.3)