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基础医学研究所

  • 姓 名:

    宋伟

  • 单 位:

    中国医学科学院基础医学研究所

  • 教职岗位:

    助理教授

  • 聘任时间:

    2024-01-01

  • 一级学科:

    生物学

  • 二级学科:

    生物化学与分子生物学

  • 联系方式:

    songwei@ibms.pumc.edu.cn

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2009060366

个人简介

宋伟,1979年出生,籍贯河北任丘,中国医学科学院基础医学研究所研究员,博士生导师。1998年考入内蒙古科技大学预防医学专业,2003年获得学士学位。2003年在河北医科大学生物化学与分子生物学专业攻读硕士学位,从事心血管分子生物学研究。2006年在北京协和医学院生物化学与分子生物学专业攻读博士学位,从事雄性生殖发育研究。2009年毕业留校工作,同年升为助理研究员。2014年升为副研究员。2020年升为研究员。


主要研究内容

本人长期致力于雄性生殖发育及相关重大疾病(不育与肿瘤)的分子机理与转化应用研究。主要研究内容:1)精原干细胞稳态与再生的调控机理研究;2)睾丸微环境调控生精细胞发育的机理研究;3)雄性生精障碍的分子机理与基因治疗研究;4)肿瘤微环境的分子调控机理与转化应用研究。 目前在Adv. Sci、 Dev Cell、Theranostics、Gut、Sci Adv、eLife、Genome Res、Cell Res、Nat. Commun、STTT等杂志发表研究论文40多篇。申请国家发明专利17项和PCT国际专利1项,已获得专利授权14项。申请并获批团标2项,专家共识1项。


代表性成果

中国足球彩票

图片

1. Pengyu Li#; Zexuan Zhang; Zihan Xie; Cheng Jin; Zhipeng Wang; Jielin Tang;  Mengzhen Li; Dingfeng Zou; Xinyu Mang; Jun Liu; Dingyao Chen; Qi Geng; Jun Zhu; Yan Lu; Changwei Yuan; Ning Zhang; Shiying Miao; Jing Peng*; Kai Li*; Wei Song*. IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals.  2025, (IF=13.638)

2. Dingfeng Zou#; Kai Li#; Luying Su#; Jun Liu; Yan Lu; Rong Huang; Mengzhen Li; Xinyu Mang; Qi Geng; Pengyu Li; Jielin Tang; Zhixin Yu; Zexuan Zhang; Dingyao Chen; Shiying Miao; Jia Yu*; Wei Yan*; Wei Song*. DDX20 is required for cell cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice, Dev. Cell 2024,59(13):1707-1723.(IF=8.7)

3. Qian Zhaoyang#; Liang Junbo#; Huang Rong#; Song Wei#; Ying Jianming*; Bi Xinyu; Zhao Jianjun; Shi Zhenyu; Liu Wenjie; Liu Jianmei; Li Zhiyu; Zhou Jianguo; Huang Zhen; Zhang Yefan; Zhao Dongbing; Wu Jianxiong; Wang Liming; Chen Xiao; Mao Rui; Zhou Yanchi; Guo Lei; Hu Hanjie; Ge Dazhuang; Li Xingchen; Luo Zhiwen; Yao Jinjie; Li Tengyan; Chen Qichen; Wang Bingzhi; Wei Zhewen; Chen Kun; Qu Chunfeng; Cai Jianqiang*; Jiao Yuchen*; Bao Li*; Zhao Hong*. HBV integrations reshaping genomic structures promote hepatocellular carcinoma, Gut, 2024, 2023(330414): 1-14.(IF=25.8)

4. Cheng Jin#, Zhipeng Wang#, Pengyu Li, Jielin Tang, Tao Jiao, Yiran Li, Jinhuan Ou, Dingfeng Zou, Mengzhen Li, Xinyu Mang, Jun Liu, Yanni Ma, Xiaolong Wu, Jie Shi, Shitao Chen, Manman He, Yan Lu, Ning Zhang, Shiying Miao, Fei Sun, Linfang Wang, Kai Li*, Jia Yu*, Wei Song*. Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans. Sci. Adv 2023, 3173:1-17. (IF=13.6)

5. Zhipeng Wang#, Cheng Jin#, Pengyu Li, Yiran Li, Jielin Tang, Zhixin Yu, Tao Jiao, Jinhuan Ou, Han Wang, Dingfeng Zou, Mengzhen Li , Xinyu Mang, Jun Liu, Yan Lu, Kai Li, Ning Zhang, Jia Yu, Shiying Miao, Linfang Wang, Wei Song*. Identiffcation of quiescent FOXC2+ spermatogonial stem cells in adult mammals. ELife 2023, 12:1-22. (IF=7.7)

6. Yalan Lu#, Rong Huang#, jianming Ying#, Xingchen Li#, Tao Jiao, Lei Guo, Haitao Zhou, Han Wang, Amannisa Tuersuntuonebit, Jianmei Liu, Qichen Chen, Yanhong Wang, Luying Su, Changyuan Guo, Fu Xu, Ziyi Wang, Yan Lu, Kai Li, Junbo Liang, Zhen Huang, Xiao Chen, Jinjie Yao, Hanjie Hu, Xiaowen Cheng, Yufeng Wan, Xinyan Chen, Ning Zhang, Shiying Miao, Jianqiang Cai, Linfang Wang, Changzheng Liu*, Wei Song*, Hong Zhao*. RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy. STTT 2022, 13;7(1):185. (IF=39.3)

7. Kai Li#, Jiayue Xu#, Yanyun Luo#, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang, Mengzhen Li, Yanmin Si,  Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long non-coding RNAs in mouse spermatogenesis. GENOME RES 2021, 31(1):13-26. (IF=9.438)

8. Shangze Li#*, Qipeng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bingxue Jin, Tianzi Liuyu, Chao Li, Xichen Huang, Runlei Du, Wei Song*, Bo Zhong*, Xiaodong Zhang*. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nat. Commun 2019, 10: 3233. (IF= 11.878)

9. Fang Wang#, Wei Song#, Hongmei Zhao, Yanni Ma, Yuxia Li, Di Zhai, Jingnan Pi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Res 2017, 27(3): 416-439. (IF=15.606)

10.Wei Song#, Wenjie Liu#, Hong Zhao, Shangze Li, Xin Guan, Jianming Ying, Yefan Zhang, Fei Miao, Mengmeng Zhang, Xiaoxia Ren, Xiaolu Li, Fan Wu, Yuechao Zhao, Yuanyuan Tian, Wenming Wu, Jun Fu, Junbo Liang, Wei Wu, Jia Yu, Shudong Zong, Shiying Miao, Xiaodong Zhang*, Linfang Wang*. Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signaling pathway. Nat. Commun 2015, 6: 8022. (IF= 11.3285)