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基础医学研究所

  • 姓 名:

    王芳

  • 单 位:

    中国医学科学院基础医学研究所

  • 教职岗位:

    助理教授

  • 聘任时间:

    2023-01-01

  • 一级学科:

    生物学

  • 二级学科:

    生物化学与分子生物学

  • 联系方式:

    wo_wfang@hotmail.com

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/ J2009060364

个人简介

王芳,教授,博士研究生导师,1983年出生,籍贯山东。2004年本科毕业于山东大学生物技术专业,同年进入医科院基础所攻读博士研究生,2009年获博士学位后,留所工作至今。2012年晋升副教授,2017年晋升教授,并于2023年获得准聘助理研究员资格。获科技部重点研发计划(青年科学家项目)”、国家“优秀青年科学基金”、医科院“青年医学人才奖励项目”、“协和新星” 等人才计划支持。作为第三完成人,获教育部自然科学二等奖。


主要研究内容

长期从事RNA调控与造血发育及疾病研究。通过RNA研究相关技术的开发,解析造血干细胞发育、分化及血液系统相关疾病发生发展的基本规律;以期为血细胞再生和血液系统疾病临床诊治提供理论基础和新方向。承担多个国家级科研项目,在Nat. Cell Biol、Cell Res、Nat. Commun等杂志发表论文20余篇。


代表性成果

中国足球彩票

图片

1.Hui Wang#, Zhaoru Zhang#, Chenxi Han#, Penglei Jiang#, Jiayue Xu#, Yingli Han#, Deyu Huang, Jian Li, Jie Zhou, Michael Durnin, Shiyuan Chen, Yaxin Liu, Jinghao Sheng, Jie Cao, Jianzhao Liu, Bing Liu*, Jia Yu*, Fang Wang*, Pengxu Qian*. SNORD113-114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery. Nat Cell Biol. 2025 Feb;27(2):246-261. (IF=19.5)

2. Weiqian Li#, Yue Huo#, Yue Ren#, Chenxi Han, Shuo Li, Kangning Wang , Manman He, Yiying Chen, Yanran Wang, Lingjie Xu, Yuehong Guo, Yanmin Si, Yufeng Gao, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Jia Yu*, Fang Wang*. Deciphering the Functional Long Non-Coding RNAs Derived from MicroRNA Loci. Adv. Sci. 2023 Nov;10(33):e2203987. (IF=14.3)

3. You Q#, Wang F#, Du R, Pi J, Wang H, Huo Y, Liu J, Wang C, Yu J*, Yang Y*, Zhu L*. m6A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Adv Mater. 2023 Feb;35(8):e2204910. (IF=27.4)

4. Xueju Wei#, Yue Huo#, Jingnan Pi#, Yufeng Gao#, Shuan Rao#, Manman He, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumorigenesis. Nat Cell Biol. 2022 Aug;24(8):1278-1290. (IF=21.3,C100)

5. Fang Wang#, Puwen Tan#, Pengcheng Zhang#, Yue Ren#, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7;8(1):eabg5369. (IF=13.6)

6. Ren Y#, Huo Y#, Li W#, He M, Liu S, Yang J, Zhao H, Xu L, Guo Y, Si Y, Zhao H, Rao S, Wang J, Ma Y, Wang X*, Yu J*, Wang F*. A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biol. 2021 Oct 14;22(1):290. (IF=18)

7. Pi J#, Wang W#, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F*, Yu J*. YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7. Cancer Res. 2021, 81(10):2651-2665. (IF=13.3, ESI)

8. Yan Huang#, Puwen Tan#, Xiaoshuang Wang, Ying Yi, Yongfei Hu, Dong Wang*, Fang Wang*. Transcriptomi c insights into temporal expression pattern of autophage genes during monocytic and granulocytic differentiation. Autophagy. 2018, 14(3): 558-559. (IF=11.1)

9.Fang Wang#, Wei Song#, Hongmei Zhao#, Yanni Ma, Yu xia Li, Di Zhai, Jingnan Pi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Res. 2017, 27(3): 416-439. (IF=15.4)

10.Zhao H#, Wang X#, Yi P, Si Y, Tan P, He J, Yu S, Ren Y, Ma Y, Zhang J, Wang D*, Wang F*, Yu J*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nat Commun. 2017, 8(1): 1428-1428. (IF=12.4)