张博，中国医学科学院北京协和医院，临床医学研究所独立PI，准聘研究员/博士研究生导师。获得国家优秀青年科学基金（2024），北京市科技新星（2022），北京协和医院中坚骨干人才（2025）等项目资助。博士毕业于北京大学（医学部）药学院，化学生物学专业，师从周德敏教授/张礼和院士，2016年入职北京协和医院，医学科学研究中心专职科研工作。

长期从事生物技术药物研究工作，针对目前内源性生物大分子在临床成药性不足的具体临床问题，聚焦于生物大分子的精准修饰和人工设计，以及工程化免疫细胞治疗技术的基础研究，探索将其应用于免疫稳态调控的新策略和新理论发现。共发表SCI论文40余篇，其中以第一或通讯作者发表于Nature BME, 风湿病顶刊Annals of the Rhe Dis, Cell Chem Bio, STTT等国际权威期刊，申请国家发明专利13项。主持或作为科技骨干承担10余项国家和省部级科研课题，包括国自然基金，重大新药创制专项等。

中国足球彩票

1.Shengjie Li#, Siyuan Yu#, Mengzhao Wang, Bo Zhang*, Yan Xu*, Synergistic potential of PD-1 blockade and IL-2 in cancer therapy via targeted bi-functional molecule design, Sci Bull (Beijing). 2025 Aug 11:S2095-9273(25)00809-6. (IF = 21.1)

2.Jiaqi Sun#, Lingfeng Guo#, Dezhong Ji#*, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang*, Demin Zhou*, Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased IL-2 PEGylates, Adv Sci (Weinh). 2025 May;12(18):e2414931. (IF = 14.9)

3.Bo Zhang#*, Jiaqi Sun#, Yeshuang Yuan#, Dezhong Ji#, Yeting Sun#, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fe, Lihe Zhang, Demin Zhou*, Xuan Zhang*, Proximity-enabled covalent binding of IL-2 to IL-2Ra selectively activates regulatory T cells and suppresses autoimmunity, Signal Transduction and Targeted Therapy, 2023, 8(1)(28). (IF = 39.3)

4.Yeting Sun#, Yeshuang Yuan, Bo Zhang*, Xuan Zhang*, CARs: a new approach for the treatment of autoimmune diseases, Sci China Life Sci. 2023 Apr;66(4): 711-728. (IF = 9.1)

5.Bo Zhang#, Jiaqi Sun#, Yan Wang#, Dezhong Ji#, Yeshuang Yuan#, Shengjie Li,  Yeting Sun, Yingqin Hou, Pengchong Li, Lidan Zhao, Fei Yu, Wenxiao Ma, Boyang Cheng, Ling Wu, Jin Hu, Min Wang, Wei Song, Xiaogang Li, Hao Li,  Yunyun Fei, Hua Chen, Lihe Zhang, George C. Tsokos*, Demin Zhou*, Xuan Zhang*, Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells, Nature biomedical engineering, 2021, 5(11): 1288-1305. (IF = 25.671)

6.Bo Zhang#,, Yan Wang#,, Yeshuang Yuan#,, Jiaqi Sun, Lulu Liu, Dan Huang, Jin Hu, Min Wang, Shengjie Li, Wei Song, Hua Chen, Demin Zhou*, Xuan Zhang*, In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells, Annals of the Rheumatic Diseases, 2021, 80(2): 176-184. (IF = 19.103)

7.Bo Zhang#, Yan Wang#, Shenlong Huang#, Jiaqi Sun, Min Wang, Wenxiao Ma,  YanboYou, Ling Wu, Jin Hu, Wei Song, Xudong Liu, Shengjie Li, Hua Chen, Guisheng Zhang, Lihe Zhang, Demin Zhou*, Lingjun Li*, Xuan Zhang*, Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator, Cell Chemical biology, 2021, 28(1): 60-69. (IF = 8.116)

8.Yuanyang Guo#, Bo Zhang#, Luying Wang, Shenlong Huang, Shilei Wang, Yanbo You, Gongming Zhu, Anlian Zhu, Mingwei Geng, Lingjun Li*, An efficient and easily-accessible ligand for Cu(I)-catalyzed azide-alkyne cycloaddition bioconjugation, Chem Commun (Camb); 2020 Nov 19;56(92):14401-14403. (IF = 5.996)

9.Bo Zhang#, Qi Yang#, Jingxian Chen, Ling Wu, Tianzhuo Yao, Yiming Wu,  Lihe Zhang, Qing Xia, Demin Zhou*, CRISPRi-Manipulation of Genetic Code Expansion via RF1 for Reassignment of Amber Codon in Bacteria, Sci Rep. 2016 Jan 28:6:20000. (IF = 4.7)

10.Bo Zhang#, Huan Xu, Jingxian Chen, Yongxiang Zheng, Yiming Wu, Longlong Si, Ling Wu, Chuanling Zhang, Gang Xia, Lihe Zhang, Demin Zhou*, Development of next generation of therapeutic IFN-a2b via genetic code, Acta Biomaterialia, 2015, Jun(19): 100-111. (IF = 6.1)