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药物研究所

  • 姓 名:

    金晶

  • 单 位:

    中国医学科学院药物研究所

  • 教职岗位:

    助理教授

  • 聘任时间:

    2024-01-01

  • 一级学科:

    药学

  • 二级学科:

    药理学

  • 联系方式:

    rebeccagold@imm.ac.cn

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2010070005

个人简介

金晶,研究员,博士研究生导师,国家高层次青年人才项目获得者。主持国家重点研发计划,国家自然科学基金面上项目等多项国家级课题。中国药理学会呼吸药理专业委员会副主任委员,中国药理学会生化与分子药理学专业委员会委员,中国药理学会抗炎免疫委员会委员,中国民族医药学会药理与毒理学分会常务理事,中国病理生理学会缺氧与呼吸专业委员会委员,北京环境诱变剂学会青年委员会副主任委员,《药学学报》和《Acta Pharmaceutica Sinica B》青年编委。


主要研究内容

长期从事肿瘤及炎症等慢性疾病的发病机制研究和创新药物研发。作为药理学科负责人,参与完成2个1类新药获CFDA 临床批件;参与完成3项成果转化。在Nature Cell Biology, Advanced Sciences等发表论文15篇;获得国内外授权专利22项;主持国家重点研发计划(2项)、国家自然科学基金等多项课题,参与国家“十二五”、“十三五”重大新药创制、国家自然科学基金重大项目等多项课题。


代表性成果

中国足球彩票

图片

1. Zhaoxin Zhang#, Shuying Li#, Fangfei Li#, Qinyan Shi, Chengyong Tan, Xiaoying Wang, Mi Li, Yunbao Liu*, Jing Jin*, Yong Li*, Shishan Yu*. Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy, Adv Sci, 12(21): e2413676. IF=14.1

2. Chunyu Zhang#, Fangfang Lai#, Hang Gong#, Shuying Li, Nan Xiang, Liuyi Que, Nina Xue, Mengyao Hao, Enjia Zhou, Xiaojian Wang*, Taigang Liang*, Jing Jin*. A Novel Dual Bruton’s Tyrosine Kinase/Janus Kinase 3 Inhibitor Wj1113 and its Therapeutic Effects on Rheumatoid Arthritis. MedComm, 6(7): e70207. (IF=10.7)

3. Zhenyuan Li#, Shuying Li#, Zeyu Xing#, Quanchang Gu, Rongrong Du, Jianshuang Jiang, Xiang Yuan, Xu Zhang, Xiaoguang Chen, Nina Xue*, Peicheng Zhang*, Jing Jin*, Yanan Yang*. Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy, J Med Chem, 67(2): 1243–1261. (IF=6.8)

4. Mengyao Hao#, Rong Fu#, Jun Tai#, Zhenhuan Tian#, Xia Yuan, Yang Chen, Mingjin Wang, Huimin Jiang, Ming Ji, Fangfang Lai, Nina Xue, Liping Bai, Yizhun Zhu, Xiaoxi Lv*, Xiaoguang Chen*, Jing Jin*. S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung, Acta Pharm Sin B, 13(3): 1110-1127IF=14.7

5. Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, Ming Ji, Nina Xue, Tingting Du, Xiaoguang Chen*, Jing Jin*. ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells. Acta Pharm Sin B, 13(12): 4733-4747. IF=14.7

6. Ruxuan Wang#, Xiaoyi Yang#, Shen You, Mengyao Hao, Jianguang Li*, Xiaoguang Chen*, Jing Jin*. Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice, Pharmaceuticals, 15(11): 1327. IF=5.2

7. Yaru Kong#, Mengyao Hao#, Aiping Chen#, Tianxing Yi, Ke Yang, Peng Li, Yi Wang, Pengfei Li, Xinbei Jia, Han Qin, Yuwei Qi, Jie Ji*, Jing Jin*, Qian Hua*, Jun Tai*. SymMap database and TMNP algorithm reveal Huanggui Tongqiao granules for Allergic rhinitis through IFN-mediated, Pharmacol Res, 185: 106483 IF=9.2

8. Minjian Yang #, Huimin Jiang #, Zhuo Yang, Xue Liu, Hanyu Sun, Mengyao Hao, Jinping Hu*, Xiaoguang Chen*, Jing Jin*, Xiaojian Wang*. Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitor, Eur J Med Chem, 241: 114611. IF=6.7

9. Jingbo Zhang #, Huimin Jiang #, Songwen Lin #, Deyu Wu, Hua Tian, Lin Jiang, Yiman Cui, Jing Jin*, Xiaoguang Chen*, Heng Xu*. Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies, J Med Chem, 65(11): 8011-8028.IF=7.3

10. Xueju Wei#, Yue Huo#, Jingnan Pi#, Yufeng Gao#, Shuan Rao #, Manman He#, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, Lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesi, Nat Cell Biol, 24(8): 1278–1290. IF=21.3