陈坚，高级研究员，博士生导师，2003年本科毕业于北京大学生命科学学院生物科学专业，2011年取得美国德克萨斯大学西南医学中心遗传与发育学博士学位，2011年至2014年，在OriGene Technologies抗体部担任研发总监，2014年至2019年，在苏州大学功能纳米与软物质研究院任特聘教授，2019年7月加入北京脑科学与类脑研究所，现任高级研究员，2022年兼任昌平实验室领衔科学家，2024年7月加入中国医学科学院北京脑和类脑研究院/北京协和医学院脑和类脑学院，现任准聘副教授。获得国家重点研发计划和国家自然科学基金等项目资助。

主要从事于神经系统肿瘤和肿瘤遗传学相关研究。发现免疫抑制中性粒细胞及其作用; 验证“肿瘤干细胞模型”并提供治疗靶点证据; 证明恶性胶质瘤来源于神经干/祖细胞; 揭示基因促骨肉瘤转移机制及治疗方案，拓展NF1在小脑发育中的新作用与治疗思路，先后在Nature、Cell、Cancer Cell、Nature Cell Biology等国际期刊发表论文40余篇，论文他引超过8300次，h-index 26（Google scholar）,学术成果入选科学网评选的“2012年世界十大科技突破”。

中国足球彩票

1. Chenhui Zhao#, Xueyan Hu#, Xiudong Guan#, Xiaojun Fu#, Tingting Wang#, Mengyuan Li, Xinze Liu, Jiarui Zhao, Di Wu, Fan Zhang, Jiaying Fu, Jiang Li, Tieqiang Zhang, Xiaochun Jiang*, Changxiang Yan*, Wang Jia*, Ence Yang*, Jian Chen*.2025. Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors. Nat Commun, 16(1), 7870. (IF=15.7)

2. Di Wu#, Ying Cao#, Hongjie Chen#, Minghao Du, Tingting Wang, Jiarui Zhao, Mengyuan Li, Wenjing Wu, Huixuan Zhang, Ence Yang*, Jing Yang*, Jian Chen*.2025. Common signatures of neutrophils in diverse disease conditions. Cell Discov, 11(1), 66.(IF=12.5)

3. Jiarui Zhao#, Di Wu#, Jiaqi Liu#, Zhang Yang, Li Chunzhao, Zhao Weichen, Cao Penghui, Wu Shixuan, Li Mengyuan, Li Wenlong, Liu Ying, Huang Yingying, Cao Ying, Sun Yiwen, Yang Ence, Nan Ji*, Jing Yang*, Jian Chen*. 2024. Disease-specific suppressive granulocytes participate in glioma progression. Cell Rep 43(12):115014. (IF=8.8)

4. Min Wu#, Tingting Wang#, Nan Ji#, Ting Lu#, Ran Yuan#, Lingxiang Wu#, Junxia Zhang, Mengyuan Li, Penghui Cao, Jiarui Zhao, Guanzhang Li, Jianyu Li, Yu Li, Yujie Tang, Zhengliang Gao, Xiuxing Wang, Wen Cheng, Ming Ge, Gang Cui, Rui Li, Anhua Wu, Yongping You*, WeiZhang*, Qianghu Wang*, Jian Chen*. 2024. Multi-omics and pharmacological characterization of patient-derived glioma cell lines. Nat Commun. 8;15(1):6740.(IF=15.7)

5. Liao D#, Zhong L#, Yin J#, Zeng C, Wang X, Huang X, Chen J, Zhang H, Zhang R, Guan XY, Shuai X, Sui J, Gao S, Deng W, Zeng YX, Shen JN*, Chen J*, Kang T*. 2020. Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma. Nature Cell Biology 22 (7), 868-881.(IF=17.7)

6. Sanchez-Ortiz E Cho W#, Nazarenko I Mo W, Chen J*, Parada LF*. 2014.NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev. 28(21) : 2407-20 .（IF=12.89)

7. J Chen#,Y Li, TS Yu, RM McKay,DK Burns, SG Kernie, LF Parada*.2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488 (7412), 522-526. (IF=38.59,C100, ESI, F1000)

8. J Chen#, RM McKay, LF Parada*. 2012. Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 149 (1), 36-47. (IF= 31.957,C100)

9. Alcantara Llaguno S#, Chen J#, Kwon CH#, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF* (2009). Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 15:45-56.（IF=25.288,C100)

10. Wang P#, Chen J#, Zheng A#, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H* (2004). Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun. 315:439-44. (IF=0.8,C100)